Speaker

Xuejun Jiang

Time

2024.10.30 16:00-17:30

Abstract

Cell death plays important role in normal biology and disease. In recent years, multiple forms of regulated cell death that are distinctive from the canonical form of programmed cell death – apoptosis – have been discovered. Among these non-apoptotic mechanisms, ferroptosis is an iron-dependent (thus the name) modality of cell death driven by phospholipid peroxidation. In this talk, our work on ferroptosis, including how we discovered that a specific metabolic form of cell death turned out to be ferroptosis, and how our work defines the intimate and seemingly counter-intuitive relationship between cellular metabolism and ferroptosis, will be discussed. Additionally, how our research reveals the role of ferroptosis in human disease, including cancer and ischemic heart disease, and the potential of targeting ferroptosis for disease treatment, will also be discussed.

Bio

Prof. Xuejun Jiang received his B.S. and M.S. degrees in Biochemistry from Fudan University in 1990 and 1993, respectively, and his Ph.D. degree in Pharmacology from the University of Texas Southwestern Medical Center in 1999, where he also spent four years of postdoctoral research focusing on the molecular mechanisms of programmed cell death before moving to Memorial Sloan Kettering Cancer Center (MSKCC) in 2003 to set up his own lab. He is currently the Virginia & Daniel K. Ludwig professor of Cell Biology at MSKCC and a professor at Weill Cornell Medical College.

Prof. Xuejun Jiang has made a series of pioneering discoveries in the areas of cell death, autophagy, and signaling. To date, he has published over one hundred papers in journals including Cell, Nature, Science, PNAS, JBC, etc., with more than 30,000 total citations by the end of 2023.