Speaker

Ze-Guang Han

Time

2021.09.29 16:00-17:30

Abstract

Some common diseases such as tumors, diabetes, cardiovascular and cerebrovascular diseases, and immune diseases seriously harm people's health. These diseases are highly complex and heterogeneous in etiology,genetic backgrounds pathogenesis and phenotype. Traditional research model is difficult to comprehensively and systematically analyze the mechanism of disease occurrence and development. Therefore, new paradigm needs to be introduced to the biomedical research, which will promote the development of new preventive, diagnostic and therapeutic approaches based on the comprehensive understanding of pathogenesis of disease occurrence and progression. Systems biomedicine may provide a new paradigm for large-scale, systematic and quantitative research of biomedical problems by using multi-omics, bioinformatics and genetic technologies. The paradigm combines hypothesis-driven research with discovery-driven research based on huge data. This paradigm considers the human body as a whole system, from the perspective of holism, to comprehensively understand the occurrence and development of these complex diseases. The approach may discover and identify new molecular markers and drug targets, and then design the innovative therapeutic methods and drugs. It can provide theoretical and technical support for predictive, personalized, preventive and participatory (4P) medicine of these complex diseases.

Bio

Ze-Guang Han MD, Chair Professor, Dean of Shanghai Center for Systems Biomedicine (SCSB) and Director of Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University. Dr. Ze-Guang Han’s current research has focused on genetics and epigenetics of liver cancer through integrating genomic, epigenomic, and transcriptomic approaches, as well as single cell analysis. His research aims to identify some oncogenes and tumor suppressor genes associated with liver cancer, where these genes or their products could be developed as diagnostic biomarkers and therapeutic targets. Prof. Han has published over 130 papers in peer-reviewed journals, including Nature, Nature Genetics, JCI, PNAS, Cancer Research and Hepatology. He won the Award of Natural Science of Shanghai for study on Schistosoma japonicum (2012), Award of Natural Science of China for study on Schistosoma japonicum (2013), Award of Natural Science of Ministry of Education on liver cancer (2016), and National “Ten thousand people plan” for leading talents.