Our country has the largest population of patients with chronic kidney diseases. Kidney fibrosis is the final common pathway of all chronic kidney diseases. Promoting cellular repair after kidney injury is critical for preventing fibrosis and improving renal function. Focusing on the mechanisms of kidney injury and repair and metabolic regulation, we have developed combinatorial indexing-based single-cell and spatial multiomics technologies. We systematically identified the diversity of injury-associated tubular cell states, revealed the role of lipid metabolism characterized by lipid droplet accumulation in early stages of kidney injury, and elucidated the diversity and functional differences of tubular cell states. These studies provide a foundation for further investigating the fate regulatory mechanisms of injury-associated cell states in kidney fibrosis. Our research group welcomes undergraduate students for open discussions and internships.

Speaker

Prof. Haikuo Li

Shanghai General Hospital

Time

 2026.4.1 12:00-13:30