Epigenetic modifications are heritable changes in the chromatin structure and gene expression that are not caused by alterations in the DNA sequence. They include >200 known types of chemical variations in the DNA DNA, RNA or proteins. Disruptions to these modifications can lead to a variety of diseases, including hereditary diseases and cancers; Meanwhile, Most RNA therapeutics have epigenetic modifications to prevent rapid elimination from the plasma and are administered intravenously or subcutaneously for effective distribution to target organs. However, >90% of unknown epigenetic modifications are not studied due to lack of methodology. 


A/Prof.Bo Cao

School of Life Sciences and Biotechnology


        2023.5.17 12:00-13:30