Adult stem cells have long been recognized as the executors of tissue homeostasis maintenance and injury regeneration, and the fountain of the organism, but the fate of adult stem cells in the body has not been systematically investigated, and many previous studies have suggested that the classical stem cell populations do not exist in a variety of organs, such as the heart and the liver. Our team found that the hematopoietic stem cells identified by scientists in vivo are not the same group of cells as the hematopoietic stem cells that are widely used by doctors in the clinic; on the other hand, our team found that the skeletal stem cells that are responsible for the growth of the bones before puberty disappeared after puberty, and were replaced by a group of skeletal stem cells that do not have the ability to increase height but only the ability to thicken, and that those that are responsible for the repair of injuries after a bone fracture are derived from the After fracture, the cells responsible for damage repair are another group of cells from the periosteum. Therefore, it can be seen that the properties and activities of adult stem cells are conditionally dependent, which puts forward a new program for the practice of stem cells and regenerative medicine.
Bo Zhou is a PIat the Center of Excellence for Innovation in Molecular Cell Science (formerly Institute of Biochemistry and Cell Biology) of the Chinese Academy of Sciences. His main research interests are hematopoietic stem cells and mesenchymal stem cells, and he has published more than 20 research papers in international academic journals such as Nature, Cell stem Cell, Nature Cell Biology, etc. He was selected by the Ministry of Organization of the Chinese Communist Party as a member of the introduction program for high-level overseas talents in 2017. he was awarded the Young Researcher Award of the China Stem Cell Association in 2018, and was awarded the Shanghai Outstanding 2022 Academic Leader.